LMPD Database

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LMP003209

UniProt Annotations

Entry Information
Gene Namesteroid receptor RNA activator 1
Protein EntryNONE_CAEEL
UniProt IDQ80VJ2
SpeciesMouse
Comments
Comment typeDescription
FunctionFunctional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).
MiscellaneousAppears to be the first example of a new class of functional RNAs also able to encode a protein.
Sequence CautionSequence=AAH26480.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH26480.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence= ; Sequence=AAH48362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAB24943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAB26893.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAE32451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the SRA1 family.
Subcellular LocationNucleus . Cytoplasm .
SubunitSRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR. {ECO:0000250|UniProtKB:Q6QGW5, ECO:0000250|UniProtKB:Q9HD15, ECO:0000269|PubMed:15327771}.