LMPD Database

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LMP003225

UniProt Annotations

Entry Information
Gene Namesialidase 4
Protein EntryNEUR4_MOUSE
UniProt IDQ8BZL1
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BZL1-2; Sequence=Displayed; Name=2; IsoId=Q8BZL1-1; Sequence=VSP_037492; Note=No experimental confirmation available.;
Catalytic ActivityHydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
FunctionMay function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids (By similarity). {ECO:0000250}.
SimilarityBelongs to the glycosyl hydrolase 33 family. {ECO:0000305}.
SimilarityContains 3 BNR repeats. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityExpressed predominantly in brain. {ECO:0000269|PubMed:14637003}.