LMPD Database

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LMP003345

Record overview

LMPD IDLMP003345
Gene ID23533
SpeciesHomo sapiens (Human)
Gene Namephosphoinositide-3-kinase, regulatory subunit 5
Gene SymbolPIK3R5
SynonymsF730038I15Rik; FOAP-2; P101-PI3K; p101
Chromosome17
Map Location17p13.1
SummaryPhosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for PIK3R5

Proteins

phosphoinositide 3-kinase regulatory subunit 5 isoform 1
Refseq ID:NP_055123
Protein GI:217330622
UniProt ID:Q8WYR1
mRNA ID:NM_014308
Length:880
RefSeq Status:REVIEWED
MQPGATTCTEDRIQHALERCLHGLSLSRRSTSWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTREVQEKGTYDLLTPLALLFYSTVLCTPHFPPDSD
LLLKAASTYHRFLTWPVPYCSICQELLTFIDAELKAPGISYQRLVRAEQGLPIRSHRSSTVTVLLLNPVEVQAEFLAVANKLSTPGHSPHSAYTTLLLHA
FQATFGAHCDVPGLHCRLQAKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAVGEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDSFDI
LQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGHCAERDSLLSTSSLASHDSTLSLASSQASGPALSRHLLTSFVSGLSDGMDSGYVEDSEESSS
EWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQ
RRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPW
EESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHS
AATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQI
KVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
 
phosphoinositide 3-kinase regulatory subunit 5 isoform 1
Refseq ID:NP_001136105
Protein GI:217330639
UniProt ID:Q8WYR1
mRNA ID:NM_001142633
Length:880
RefSeq Status:REVIEWED
Protein sequence is identical to GI:217330622 (mRNA isoform)
 
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID:NP_001238781
Protein GI:353411950
UniProt ID:Q8WYR1
mRNA ID:NM_001251852
Length:494
RefSeq Status:REVIEWED
MDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGT
QLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDS
PRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEK
TTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNS
KSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
 
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID:NP_001238784
Protein GI:353523787
UniProt ID:Q8WYR1
mRNA ID:NM_001251855
Length:494
RefSeq Status:REVIEWED
Protein sequence is identical to GI:353411950 (mRNA isoform)
 
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID:NP_001238780
Protein GI:353523783
UniProt ID:Q8WYR1
mRNA ID:NM_001251851
Length:494
RefSeq Status:REVIEWED
Protein sequence is identical to GI:353411950 (mRNA isoform)
 
phosphoinositide 3-kinase regulatory subunit 5 isoform 2
Refseq ID:NP_001238782
Protein GI:353523785
UniProt ID:Q8WYR1
mRNA ID:NM_001251853
Length:494
RefSeq Status:REVIEWED
Protein sequence is identical to GI:353411950 (mRNA isoform)