LMPD Database

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LMP003467

UniProt Annotations

Entry Information
Gene Namemembrane bound O-acyltransferase domain containing 1
Protein EntryMBOA1_MOUSE
UniProt IDQ8BH98
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=4.7 uM for oleoyl-CoA (in the presence of LPE C18:1 as cosubstrate) {ECO:0000269|PubMed:18287005}; KM=3.9 uM for oleoyl-CoA (in the presence of LPS C18:1 as cosubstrate) {ECO:0000269|PubMed:18287005}; KM=7.75 uM for LPE C18:1 (in the presence of oleoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18287005}; KM=2.25 uM for LPS C18:1 (in the presence of oleoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18287005}; Vmax=9.125 nmol/min/mg enzyme with oleoyl-CoA and LPE C18:1 as substrates {ECO:0000269|PubMed:18287005}; Vmax=4.7 nmol/min/mg enzyme with oleoyl-CoA and LPS C18:1 as substrates {ECO:0000269|PubMed:18287005};
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidylserine (1-acyl-2- hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18287005}.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:18287005}.
Tissue SpecificityHighly expressed in stomach, epididymis, and colon. {ECO:0000269|PubMed:18287005}.