LMPD Database

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LMP003662

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 4
Protein EntryLPCT4_MOUSE
UniProt IDQ6NVG1
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. {ECO:0000269|PubMed:18156367}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. {ECO:0000269|PubMed:18156367}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:18156367}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. {ECO:0000269|PubMed:18156367}.
Catalytic ActivityAcyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine. {ECO:0000269|PubMed:18156367}.
FunctionDisplays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity). Converts lysophosphatidylcholine to phosphatidycholine. {ECO:0000250, ECO:0000269|PubMed:18156367}.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityWidely expressed with much higher level in brain. Expressed in erythroleukemic cells but not in reticulocytes. {ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:18458083}.