LMPD Database

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LMP004020

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase 2
Protein EntryPGES2_MOUSE
UniProt IDQ8BWM0
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate. {ECO:0000250|UniProtKB:Q9H7Z7}.
Enzyme RegulationIsomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by glutathione (GSH) and 2-mercaptoethanol. {ECO:0000250|UniProtKB:Q66LN0}.
FunctionIsomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. {ECO:0000250|UniProtKB:Q9H7Z7, ECO:0000303|PubMed:12050152}.
InductionConstitutively expressed. Not induced during tissue inflammation. Down-regulated in the absence of Ptges. {ECO:0000269|PubMed:12835322, ECO:0000269|PubMed:15584915}.
PathwayLipid metabolism; prostaglandin biosynthesis.
SimilarityBelongs to the GST superfamily. {ECO:0000305}.
SimilarityContains 1 glutaredoxin domain. {ECO:0000255|PROSITE- ProRule:PRU00686}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250|UniProtKB:Q9H7Z7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H7Z7}. Nucleus {ECO:0000269|PubMed:12050152}. Note=According to PubMed:12050152, some fraction may be nuclear. {ECO:0000269|PubMed:12050152}.
Subcellular LocationProstaglandin E synthase 2 truncated form: Cytoplasm. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form.
SubunitHomodimer. Interacts with EXOSC10 (By similarity). May interact with CEBPB. {ECO:0000250|UniProtKB:Q66LN0, ECO:0000250|UniProtKB:Q9H7Z7, ECO:0000269|PubMed:15879117}.
Tissue SpecificityWidely expressed. Expressed in brain, heart, liver, colon and lung. {ECO:0000269|PubMed:12050152, ECO:0000269|PubMed:12835322}.