LMPD Database

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LMP004109

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 11
Protein EntryDHB11_MOUSE
UniProt IDQ9EQ06
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EQ06-1; Sequence=Displayed; Name=2; IsoId=Q9EQ06-2; Sequence=VSP_015013, VSP_015014; Note=No experimental confirmation available.;
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H. {ECO:0000269|PubMed:11165019}.
FunctionCan convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000305}. Cytoplasm. Note=According to PubMed:12697717 it is cytoplasmic. However, the relevance of such result remains unclear.