LMPD Database

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LMP004460

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol transfer protein, cytoplasmic 1
Protein EntryPITC1_MOUSE
UniProt IDQ8K4R4
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=mM-rdgBbeta; IsoId=Q8K4R4-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; Synonyms=mM-rdgBbeta1; IsoId=Q8K4R4-2; Sequence=VSP_025549, VSP_025551; Name=3; IsoId=Q8K4R4-3; Sequence=VSP_025548, VSP_025550; Note=No experimental confirmation available.; Name=4; IsoId=Q8K4R4-4; Sequence=VSP_025546, VSP_025547; Note=No experimental confirmation available.;
FunctionPhosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Isoform 2 specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development. {ECO:0000269|PubMed:12562526}.
Sequence CautionSequence=CAM17314.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM17315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM20627.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM25441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM25442.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the PtdIns transfer protein family. PI transfer class IIB subfamily. {ECO:0000305}.
Subcellular LocationIsoform 1: Cytoplasm.
Subcellular LocationIsoform 2: Cytoplasm. Nucleus.
Tissue SpecificityIsoform 1 is widely expressed. Isoform 2 is weakly expressed. In brain, isoform 2 is weakly expressed and is rather confined to the embryonic stage. In contrast, isoform 1 is widely expressed in brain, with expression in the gray matters of pre- and postnatal brains. {ECO:0000269|PubMed:12562526}.