LMPD Database

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LMP004462

UniProt Annotations

Entry Information
Gene Nameserum deprivation response
Protein EntryQ63918_MOUSE
UniProt IDQ63918
SpeciesMouse
Comments
Comment typeDescription
Developmental StageExpression gradually increases during embryonic stages and reaches a maximum in neonates.
FunctionMay play a role in targeting PRKCA to caveolae.
InductionUp-regulated in response to cardiac hypertrophy and in serum-starved but not in density-dependent growth-arrested NIH3T3 cells. Down-regulated within 6 hours after the addition of serum or epidermal growth factor to serum-starved cells.
MiscellaneousBinds phosphatidylserine (PS) in a calcium- independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine (By similarity).
PtmThe N-terminus is blocked.
SimilarityBelongs to the PTRF/SDPR family.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:18332105}. Membrane, caveola . Note=Colocalizes with CAV1 to caveolae.
SubunitBinds to PRKCA in the presence of phosphatidylserine. Interacts with MURC; this augments the transactivation of NPPA by MURC (By similarity).
Tissue SpecificityHighly expressed in kidney, lung and heart, and expressed at lower levels in liver, spleen, thymus, stomach, intestine and uterus.