LMPD Database

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LMP005253

UniProt Annotations

Entry Information
Gene Namesolute carrier family 27 (fatty acid transporter), member 1
Protein EntryS27A1_HUMAN
UniProt IDQ6PCB7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCB7-1; Sequence=Displayed; Name=2; IsoId=Q6PCB7-2; Sequence=VSP_055806, VSP_055807; Note=No experimental confirmation available.;
FunctionInvolved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
MiscellaneousFATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family.
Subcellular LocationCell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm . Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity).
SubunitSelf-associates. May function as a homodimer (By similarity).
Tissue SpecificityHighest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.