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LMP005773

Record overview

LMPD IDLMP005773
Gene ID14778
SpeciesMus musculus(Mouse)
Gene Nameglutathione peroxidase 3
Gene SymbolGpx3
SynonymsAA960521; EGPx; GPx; GSHPx-3; GSHPx-P
Alternate namesglutathione peroxidase 3; GPx-3; GPx-P; plasma GPx; extracellular GPx; plasma glutathione peroxidase
Chromosome11
Map Location11|11 B3-B5
EC Number1.11.1.9
SummaryThis gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is highly expressed in the kidney where it may play a role in protecting the kidney from oxidative damage. [provided by RefSeq, Feb 2012]
OrthologsView orthologs and multiple alignments for Gpx3

Proteins

glutathione peroxidase 3 precursor
Refseq ID:NP_032187
Protein GI:15011841
UniProt ID:P46412
mRNA ID:NM_008161
Length:226
RefSeq Status:REVIEWED
MARILRASCLLSLLLAGFVPPGRGQEKSKTDCHGGMSGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVASYUGLTDQYLELNALQEELGPFGLVILGFP
SNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTAELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPVMRWYH
RTTVSNVKMDILSYMRRQAALSARGK
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2512
peptide sequence: 
MARILRASCLLSLLLAGFVPPGRG