LMPD Database

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LMP006292

UniProt Annotations

Entry Information
Gene NameUDP-glucose glycoprotein glucosyltransferase 1
Protein EntryQ6P5E4_MOUSE
UniProt IDQ6P5E4
SpeciesMouse
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ;
DomainThe N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
FunctionRecognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 8 family.
Subcellular LocationEndoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9NYU2, ECO:0000255|PROSITE- ProRule:PRU10138}. Endoplasmic reticulum-Golgi intermediate compartment .
SubunitMonomer as well as in a tight complex with SEP15. Interacts with METTL23 (By similarity).