LMPD Database

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LMP006370

UniProt Annotations

Entry Information
Gene Namesphingomyelin phosphodiesterase 4
Protein EntryNSMA3_MOUSE
UniProt IDQ6ZPR5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6ZPR5-1; Sequence=Displayed; Name=2; IsoId=Q6ZPR5-2; Sequence=VSP_022485; Name=3; IsoId=Q6ZPR5-3; Sequence=VSP_022485, VSP_022486; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZPR5-4; Sequence=VSP_022485, VSP_022487; Note=No experimental confirmation available.; Name=5; IsoId=Q6ZPR5-5; Sequence=VSP_022484, VSP_022485; Note=No experimental confirmation available.;
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Enzyme RegulationActivated by phosphatidylserine and tumor necrosis factor (TNF). Inhibited by scyphostatin (By similarity). {ECO:0000250}.
FunctionCatalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000250}.
Sequence CautionSequence=BAC98164.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}.