LMPD Database

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LMP006566

UniProt Annotations

Entry Information
Gene Nameenoyl Coenzyme A hydratase domain containing 1
Protein EntryECHD1_MOUSE
UniProt IDQ9D9V3
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9V3-1; Sequence=Displayed; Name=2; IsoId=Q9D9V3-2; Sequence=VSP_022499; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.96 uM for (S)-ethylmalonyl-CoA (in presence of 0 mM of ATP) {ECO:0000269|PubMed:22016388}; KM=6.5 uM for (S)-ethylmalonyl-CoA (in presence of 5 mM of ATP) {ECO:0000269|PubMed:22016388}; KM=3.1 uM for (S)-methylmalonyl-CoA (in presence of 0 mM of ATP) {ECO:0000269|PubMed:22016388}; KM=15.1 uM for (S)-methylmalonyl-CoA (in presence of 5 mM of ATP) {ECO:0000269|PubMed:22016388};
Catalytic Activity(S)-ethylmalonyl-CoA = butanoyl-CoA + CO(2). {ECO:0000269|PubMed:22016388}.
Catalytic Activity(S)-methylmalonyl-CoA = propanoyl-CoA + CO(2). {ECO:0000269|PubMed:22016388}.
FunctionDecarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level. {ECO:0000269|PubMed:22016388}.
SimilarityBelongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000305|PubMed:22016388}.