LMPD Database

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LMP006588

UniProt Annotations

Entry Information
Gene Namephospholipase C, eta 1
Protein EntryPLCH1_MOUSE
UniProt IDQ4KWH5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=PLC-eta-1; IsoId=Q4KWH5-1; Sequence=Displayed; Name=2; IsoId=Q4KWH5-2; Sequence=VSP_032908, VSP_032909, VSP_032911; Note=No experimental confirmation available.; Name=3; Synonyms=PLC-eta-1b; IsoId=Q4KWH5-3; Sequence=VSP_032912, VSP_032915; Name=4; Synonyms=PLC-eta-1a; IsoId=Q4KWH5-4; Sequence=VSP_032913, VSP_032914; Name=5; IsoId=Q4KWH5-5; Sequence=VSP_032907, VSP_032910, VSP_032911, VSP_032912, VSP_032915; Note=No experimental confirmation available.;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationCytoplasm. Membrane {ECO:0000250}.
Tissue SpecificityExpressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. {ECO:0000269|PubMed:15702972}.