LMPD Database

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LMP006632

UniProt Annotations

Entry Information
Gene Namephospholipase C-like 2
Protein EntryPLCL2_HUMAN
UniProt IDQ9UPR0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UPR0-1; Sequence=Displayed; Name=2; IsoId=Q9UPR0-2; Sequence=VSP_025790, VSP_025791, VSP_025792; Note=No experimental confirmation available.; Name=3; IsoId=Q9UPR0-3; Sequence=VSP_025790;
CautionIn the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.
FunctionMay play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
Sequence CautionSequence=BAA83044.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
Subcellular LocationCytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.