LMPD Database

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LMP006640

UniProt Annotations

Entry Information
Gene Namephospholipase C, delta 4
Protein EntryPLCD4_HUMAN
UniProt IDQ9BRC7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRC7-1; Sequence=Displayed; Note=Acceptor splice site between exons 4 and 5 is non-canonical but conserved through species for that particular gene.; Name=2; Synonyms=PLCD4b; IsoId=Q9BRC7-2; Sequence=VSP_028501, VSP_028502; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI
DomainThe C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
DomainThe PDZ-binding motif mediates the interaction with GRIP1.
DomainThe PH domain is not a critical determinant of the membrane localization.
FunctionHydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
SimilarityContains 3 EF-hand domains. {ECO
Subcellular LocationMembrane ; Peripheral membrane protein {ECO
SubunitInteracts with GRIP1.
Tissue SpecificityHighly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO