LMPD Database

LMP006659

Gene Information

Entrez Gene ID	3635
Gene Name	inositol polyphosphate-5-phosphatase, 145kDa
Gene Symbol	INPP5D
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0016020	IEA:UniProtKB-KW	C	membrane
GO:0004445	TAS:ProtInc	F	inositol-polyphosphate 5-phosphatase activity
GO:0034594	IEA:Ensembl	F	phosphatidylinositol trisphosphate phosphatase activity
GO:0006915	IEA:UniProtKB-KW	P	apoptotic process
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0008340	IEA:Ensembl	P	determination of adult lifespan
GO:0016064	IEA:Ensembl	P	immunoglobulin mediated immune response
GO:0043647	TAS:Reactome	P	inositol phosphate metabolic process
GO:0035556	IEA:Ensembl	P	intracellular signal transduction
GO:0050900	TAS:Reactome	P	leukocyte migration
GO:0030889	IEA:Ensembl	P	negative regulation of B cell proliferation
GO:0045779	IEA:Ensembl	P	negative regulation of bone resorption
GO:0050777	IEA:Ensembl	P	negative regulation of immune response
GO:0045409	IEA:Ensembl	P	negative regulation of interleukin-6 biosynthetic process
GO:0045656	IEA:Ensembl	P	negative regulation of monocyte differentiation
GO:0045659	IEA:Ensembl	P	negative regulation of neutrophil differentiation
GO:0045671	IEA:Ensembl	P	negative regulation of osteoclast differentiation
GO:0009968	IEA:Ensembl	P	negative regulation of signal transduction
GO:0006796	TAS:ProtInc	P	phosphate-containing compound metabolic process
GO:0006661	TAS:Reactome	P	phosphatidylinositol biosynthetic process
GO:0046856	IEA:InterPro	P	phosphatidylinositol dephosphorylation
GO:0006644	TAS:Reactome	P	phospholipid metabolic process
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0045579	IEA:Ensembl	P	positive regulation of B cell differentiation
GO:0045648	IEA:Ensembl	P	positive regulation of erythrocyte differentiation
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0050852	TAS:Reactome	P	T cell receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_150312	Synthesis of IP3 and IP4 in the cytosol