LMPD Database

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LMP006662

UniProt Annotations

Entry Information
Gene Namephospholipase C, eta 1
Protein EntryPLCH1_HUMAN
UniProt IDQ4KWH8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PLC-eta-1; IsoId=Q4KWH8-1; Sequence=Displayed; Name=2; IsoId=Q4KWH8-2; Sequence=VSP_032901, VSP_032902; Note=No experimental confirmation available.; Name=3; Synonyms=PLC-eta-1a; IsoId=Q4KWH8-3; Sequence=VSP_032904, VSP_032905; Name=4; IsoId=Q4KWH8-4; Sequence=VSP_032902, VSP_032903, VSP_032906; Note=No experimental confirmation available.;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence CautionSequence=BAB14129.1; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
SimilarityContains 2 EF-hand domains. {ECO
Subcellular LocationCytoplasm . Membrane .
Tissue SpecificityExpressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.