LMPD Database

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LMP006667

UniProt Annotations

Entry Information
Gene Nameethylmalonyl-CoA decarboxylase 1
Protein EntryECHD1_HUMAN
UniProt IDQ9NTX5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9NTX5-1; Sequence=Displayed; Name=2; IsoId=Q9NTX5-2; Sequence=VSP_022498; Name=3; IsoId=Q9NTX5-3; Sequence=VSP_042581; Note=No experimental confirmation available.; Name=4; Synonyms=HEL-S-76; IsoId=Q9NTX5-4; Sequence=VSP_042581, VSP_042583; Name=5; IsoId=Q9NTX5-5; Sequence=VSP_022498, VSP_042583; Note=No experimental confirmation available.; Name=6; IsoId=Q9NTX5-6; Sequence=VSP_022498, VSP_042582; Note=No experimental confirmation available.;
Catalytic Activity(S)-ethylmalonyl-CoA = butanoyl-CoA + CO(2).
Catalytic Activity(S)-methylmalonyl-CoA = propanoyl-CoA + CO(2).
FunctionDecarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Sequence CautionSequence=AAF67657.1; Type=Frameshift; Positions=121, 123, 125; Evidence= ; Sequence=CAI20295.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=CAI20297.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the enoyl-CoA hydratase/isomerase family.
Subcellular LocationCytoplasm, cytosol .