LMPD Database

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LMP006683

UniProt Annotations

Entry Information
Gene Namescavenger receptor class F, member 1
Protein EntrySREC_HUMAN
UniProt IDQ14162
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=SREC-1; IsoId=Q14162-1; Sequence=Displayed; Name=2; Synonyms=SREC-5; IsoId=Q14162-2; Sequence=VSP_039956; Name=3; Synonyms=SREC-3; IsoId=Q14162-3; Sequence=VSP_039960, VSP_039961; Name=4; Synonyms=SREC-4; IsoId=Q14162-4; Sequence=VSP_039957; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=SREC-2; IsoId=Q14162-5; Sequence=VSP_039958, VSP_039959; Note=No experimental confirmation available.;
FunctionMediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).
SimilarityContains 6 EGF-like domains. {ECO
Subcellular LocationMembrane ; Single-pass type I membrane protein .
SubunitHeterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).
Tissue SpecificityEndothelial cells.