LMPD Database

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LMP006688

UniProt Annotations

Entry Information
Gene Namearylsulfatase E (chondrodysplasia punctata 1)
Protein EntryARSE_HUMAN
UniProt IDP51690
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7.; Temperature dependence: Almost completely inactivated after 10 minutes at 50 degrees Celsius.;
CofactorName=Ca(2+); Xref=ChEBI
DiseaseChondrodysplasia punctata 1, X-linked recessive (CDPX1) [MIM
Enzyme RegulationInhibited by millimolar concentrations of warfarin.
FunctionMay be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.
PtmN-glycosylated.
PtmThe conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
SimilarityBelongs to the sulfatase family.
Subcellular LocationGolgi apparatus, Golgi stack.
Tissue SpecificityExpressed in the pancreas, liver and kidney.