LMPD Database

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LMP006700

UniProt Annotations

Entry Information
Gene NameStAR-related lipid transfer (START) domain containing 13
Protein EntrySTA13_HUMAN
UniProt IDQ9Y3M8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=DLC2alpha; IsoId=Q9Y3M8-1; Sequence=Displayed; Name=2; Synonyms=DLC2beta; IsoId=Q9Y3M8-2; Sequence=VSP_017354; Name=3; Synonyms=DLC2gamma; IsoId=Q9Y3M8-3; Sequence=VSP_017353; Name=4; IsoId=Q9Y3M8-4; Sequence=VSP_017355; Name=5; IsoId=Q9Y3M8-5; Sequence=VSP_017354, VSP_017356, VSP_017357;
FunctionGTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
InteractionQ86VP1:TAX1BP1; NbExp=2; IntAct=EBI-465487, EBI-529518;
SimilarityContains 1 Rho-GAP domain. {ECO
SimilarityContains 1 SAM (sterile alpha motif) domain.
SimilarityContains 1 START domain. {ECO
Subcellular LocationCytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
SubunitHomodimer. Interacts with TAX1BP1.
Tissue SpecificityUbiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/STARD13ID44051ch13q13.html";