LMPD Database

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LMP006706

UniProt Annotations

Entry Information
Gene NameNAD(P) dependent steroid dehydrogenase-like
Protein EntryNSDHL_HUMAN
UniProt IDQ15738
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityA 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
DiseaseCK syndrome (CKS) [MIM
DiseaseCongenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) [MIM
FunctionInvolved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
SimilarityBelongs to the 3-beta-HSD family.
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass membrane protein . Lipid droplet . Note=Trafficking through the Golgi is necessary for ER membrane localization.
Tissue SpecificityBrain, heart, liver, lung, kidney, skin and placenta.