LMPD Database

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LMP006720

UniProt Annotations

Entry Information
Gene Namemonoacylglycerol O-acyltransferase 3
Protein EntryMOGT3_HUMAN
UniProt IDQ86VF5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86VF5-1; Sequence=Displayed; Name=2; IsoId=Q86VF5-2; Sequence=VSP_020361, VSP_020362; Note=No experimental confirmation available.; Name=3; IsoId=Q86VF5-3; Sequence=VSP_020363; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: Vmax=9.3 nmol/min/mg enzyme with diacylglycerol as substrate ; Vmax=22.8 nmol/min/mg enzyme with 2-monoacylglycerol as substrate ;
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Catalytic ActivityAcyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
FunctionCatalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.
PathwayGlycerolipid metabolism; triacylglycerol biosynthesis.
Sequence CautionSequence=AAD45832.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the diacylglycerol acyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Tissue SpecificitySelectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver.