LMPD Database

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LMP006730

UniProt Annotations

Entry Information
Gene NameStAR-related lipid transfer (START) domain containing 8
Protein EntrySTAR8_HUMAN
UniProt IDQ92502
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=DLC3beta; IsoId=Q92502-1; Sequence=Displayed; Name=2; Synonyms=DLC3alpha; IsoId=Q92502-2; Sequence=VSP_032984; Note=Ref.3 (CAH18253) sequence is in conflict in position: 71:D->G. No experimental confirmation available. ;
FunctionAccelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1.
Sequence CautionSequence=BAA11506.2; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 Rho-GAP domain. {ECO
SimilarityContains 1 START domain. {ECO
Subcellular LocationCell junction, focal adhesion .
SubunitBinds both the SH2 and PTB domains of TNS1.
Tissue SpecificityWidely expressed with highest levels in kidney, lung and placenta.