LMPD Database

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LMP006783

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class Y
Protein EntryPIGY_HUMAN
UniProt IDQ3MUY2
SpeciesHuman
Comments
Comment typeDescription
FunctionComponent of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI- anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.
MiscellaneousPREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
SubunitInteracts with the GPI-GnT complex composed of PIGA, PIGC, PIGH, PIGP, PIGQ and DPM2. Interacts directly with PIGA. Does not interact with Ras proteins.