LMPD Database

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LMP006819

UniProt Annotations

Entry Information
Gene Namealpha-ketoglutarate dehydrogenase KGD2
Protein EntryODO2_YEAST
UniProt IDP19262
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivitySuccinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
FunctionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
InductionTranscriptionally regulated by glucose and activated by the HAP2 and HAP3 proteins.
InteractionP19955:YMR31; NbExp=3; IntAct=EBI-12464, EBI-16295;
MiscellaneousPresent with 7970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayAmino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
SimilarityBelongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
SimilarityContains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular LocationMitochondrion.