LMPD Database

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LMP006820

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol phospholipase C
Protein EntryPLC1_YEAST
UniProt IDP32383
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1. {ECO:0000269|PubMed:12073033}.
InteractionQ06132:SGD1; NbExp=3; IntAct=EBI-13485, EBI-34377;
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
SubunitInteracts with SGD1. {ECO:0000269|PubMed:12073033}.