LMPD Database

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LMP006821

UniProt Annotations

Entry Information
Gene Namefarnesyltranstransferase
Protein EntryGGPPS_YEAST
UniProt IDQ12051
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=3.2 uM for farnesyl diphosphate; KM=0.8 uM for isopentenyl diphosphate;
Catalytic Activity(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Catalytic ActivityDimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic ActivityGeranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17535895}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000269|PubMed:17535895};
FunctionCatalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting. {ECO:0000269|PubMed:15296494, ECO:0000269|PubMed:7665600}.
MiscellaneousPresent with 2840 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
SimilarityBelongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.