LMPD Database

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LMP006861

UniProt Annotations

Entry Information
Gene Namebranched-chain-amino-acid transaminase BAT1
Protein EntryBCA1_YEAST
UniProt IDP38891
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityL-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate.
Catalytic ActivityL-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate.
Catalytic ActivityL-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Developmental StageHighly expressed during logarithmic phase of growth. Down-regulated during the stationary phase.
FunctionInvolved in the biosynthesis of the branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as the amino donors. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1
FunctionInvolved in the biosynthesis of the branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as the amino donors. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1. {ECO:0000269|PubMed:18625006, ECO:0000269|PubMed:21267457}.
InductionMainly expressed on ammonium-glucose exponential cultures (biosynthetic conditions), and repressed in the presence of leucine, isoleucine or valine
InductionMainly expressed on ammonium-glucose exponential cultures (biosynthetic conditions), and repressed in the presence of leucine, isoleucine or valine. {ECO:0000269|PubMed:21267457}.
MiscellaneousPresent with 87300 molecules/cell in log phase SD medium
MiscellaneousPresent with 87300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayAmino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate: step 4/4.
PathwayAmino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate: step 4/4.
PathwayAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6.
PathwayAmino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.
SimilarityBelongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SimilarityBelongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix .
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:21267457}.