LMPD Database

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LMP006872

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate kinase KCS1
Protein EntryKCS1_YEAST
UniProt IDQ12494
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=3.3 uM for InsP6 {ECO:0000269|PubMed:10827188}; KM=1.2 uM for InsP5 {ECO:0000269|PubMed:10827188}; Vmax=2 umol/min/mg enzyme {ECO:0000269|PubMed:10827188};
Biophysicochemical PropertiesKinetic parameters: KM=3.3 uM for InsP6 ; KM=1.2 uM for InsP5 ; Vmax=2 umol/min/mg enzyme ;
Catalytic ActivityATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic ActivityATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
FunctionConverts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance. {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:10827188, ECO:0000269|PubMed:11956213, ECO:0000269|PubMed:15561716, ECO:0000269|PubMed:15866881, ECO:0000269|PubMed:15944147, ECO:0000269|PubMed:8601473}.
MiscellaneousPresent with 1940 molecules/cell in log phase SD medium
MiscellaneousPresent with 1940 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the inositol phosphokinase (IPK) family
SimilarityBelongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular LocationCytoplasm .
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14562095}.