LMPD Database

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LMP006885

UniProt Annotations

Entry Information
Gene NameEri1p
Protein EntryERI1_YEAST
UniProt IDP62651
SpeciesYeast (S288c)
Comments
Comment typeDescription
Disruption PhenotypeDefects cause hyperactive Ras phenotypes, probably due to diminished GPI-anchor protein production. {ECO:0000269|PubMed:12832483}.
FunctionProbable component of the GPI-GlcNAc transferase (GPI- GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI- anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2. {ECO:0000269|PubMed:12832483, ECO:0000269|PubMed:15163411}.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12832483}; Multi-pass membrane protein {ECO:0000269|PubMed:12832483}.
SubunitInteracts with GTP-bound RAS2 in an effector loop- dependent manner. Interacts with GPI2, suggesting that it is a component of the GPI-GnT complex, probably composed of GPI1, GPI2, GPI3, GPI15 and ERI1. {ECO:0000269|PubMed:12832483, ECO:0000269|PubMed:15163411}.