LMPD Database

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LMP006889

UniProt Annotations

Entry Information
Gene Namephosphoinositide 5-phosphatase INP54
Protein EntryINP54_YEAST
UniProt IDQ08227
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
FunctionRegulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3- phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). {ECO:0000269|PubMed:10660045, ECO:0000269|PubMed:11116155}.
MiscellaneousPresent with 1200 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:11116155}; Peripheral membrane protein {ECO:0000269|PubMed:11116155}; Cytoplasmic side {ECO:0000269|PubMed:11116155}.