LMPD Database

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LMP006893

UniProt Annotations

Entry Information
Gene NameLsp1p
Protein EntryLSP1_YEAST
UniProt IDQ12230
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionTogether with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress
FunctionTogether with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress. {ECO:0000269|PubMed:15016821}.
MiscellaneousPresent with 104485 molecules/cell in log phase SD medium
MiscellaneousPresent with 104485 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmN-glycosylated
PtmN-glycosylated. {ECO:0000269|PubMed:19756047}.
PtmPhosphorylated by PKH1 and PKH2. Phosphorylation is stimulated by sphingolipid long chain bases (LCBs). {ECO:0000269|PubMed:15016821, ECO:0000269|PubMed:15665377, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}.
Subcellular LocationCytoplasm, cell cortex {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16496001}. Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Subcellular LocationCytoplasm, cell cortex . Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.