LMPD Database

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LMP006903

UniProt Annotations

Entry Information
Gene Namehexaprenyldihydroxybenzoate methyltransferase
Protein EntryCOQ3_YEAST
UniProt IDP27680
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-methionine + 2-hexaprenyl-3- methyl-5-hydroxy-6-methoxy-1,4-benzoquinol = S-adenosyl-L- homocysteine + ubiquinol. {ECO:0000269|PubMed:10419476}.
Catalytic ActivityS-adenosyl-L-methionine + 3,4-dihydroxy-5-all- trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy- 4-hydroxy-5-all-trans-polyprenylbenzoate. {ECO:0000269|PubMed:10419476}.
Catalytic ActivityS-adenosyl-L-methionine + 3-(all-trans- polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2- methoxy-6-(all-trans-polyprenyl)phenol. {ECO:0000269|PubMed:10419476}.
Catalytic ActivityS-adenosyl-L-methionine + 3- demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. {ECO:0000269|PubMed:10419476}.
Enzyme RegulationRegulated in response to catabolite repression.
FunctionNon-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway. {ECO:0000269|PubMed:10419476}.
MiscellaneousPresent with 259 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
Sequence CautionSequence=AAB63972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA88165.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA99108.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA99109.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the methyltransferase superfamily. UbiG/COQ3 family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane {ECO:0000269|PubMed:10419476, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Peripheral membrane protein {ECO:0000269|PubMed:10419476, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Matrix side {ECO:0000269|PubMed:10419476, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
SubunitInteracts with COQ4. {ECO:0000269|PubMed:15792955}.