LMPD Database

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LMP006921

UniProt Annotations

Entry Information
Gene Namephosphoinositide 5-phosphatase INP51
Protein EntryINP51_YEAST
UniProt IDP40559
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Enzyme RegulationIRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover
Enzyme RegulationIRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. {ECO:0000269|PubMed:15265867}.
FunctionControls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth. {ECO:0000269|PubMed:11311145, ECO:0000269|PubMed:15265867, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:15691741, ECO:0000269|PubMed:17452534, ECO:0000269|PubMed:9265642, ECO:0000269|PubMed:9560389, ECO:0000269|PubMed:9788876}.
InteractionP36115:IRS4; NbExp=3; IntAct=EBI-24915, EBI-27090; P47030:TAX4; NbExp=3; IntAct=EBI-24915, EBI-25970;
MiscellaneousPresent with 98 molecules/cell in log phase SD medium
MiscellaneousPresent with 98 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the synaptojanin family
SimilarityBelongs to the synaptojanin family. {ECO:0000305}.
SimilarityContains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
SimilarityIn the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family
SimilarityIn the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton, actin patch .
Subcellular LocationCytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:14562095}.
SubunitInteracts with IRS4 and TAX4
SubunitInteracts with IRS4 and TAX4. {ECO:0000269|PubMed:15265867}.