LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006922

UniProt Annotations

Entry Information
Gene NameEnt1p
Protein EntryENT1_YEAST
UniProt IDQ12518
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionBinds to membranes enriched in phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Negatively regulated via phosphorylation. {ECO:0000269|PubMed:10449404, ECO:0000269|PubMed:11694597, ECO:0000269|PubMed:12529323}.
SimilarityBelongs to the epsin family. {ECO:0000305}.
SimilarityContains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00243}.
SimilarityContains 2 UIM (ubiquitin-interacting motif) repeats. {ECO:0000255|PROSITE-ProRule:PRU00213}.
Subcellular LocationCytoplasm. Membrane; Peripheral membrane protein. Note=Localizes in a punctate pattern. Found in the actin cortical patches.
SubunitInteracts with EDE1 and PAN1. {ECO:0000269|PubMed:11694597, ECO:0000269|PubMed:12529323}.