LMPD Database

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LMP006930

UniProt Annotations

Entry Information
Gene Namehydroxymethylglutaryl-CoA synthase
Protein EntryHMCS_YEAST
UniProt IDP54839
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
FunctionThis enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase
FunctionThis enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. {ECO:0000250}.
InteractionP53090:ARO8; NbExp=1; IntAct=EBI-8373, EBI-2042933; P21524:RNR1; NbExp=1; IntAct=EBI-8373, EBI-15234; P20434:RPB5; NbExp=1; IntAct=EBI-8373, EBI-15781;
MiscellaneousPresent with 34800 molecules/cell in log phase SD medium
MiscellaneousPresent with 34800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
SimilarityBelongs to the HMG-CoA synthase family
SimilarityBelongs to the HMG-CoA synthase family. {ECO:0000305}.