LMPD Database

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LMP006942

UniProt Annotations

Entry Information
Gene NameSpt14p
Protein EntryGPI3_YEAST
UniProt IDP32363
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol.
CautionWas originally thought to be involved in transcription
CautionWas originally thought to be involved in transcription. {ECO:0000305|PubMed:1660567}.
Enzyme RegulationInhibited by Ras, probably via the interaction between RAS2 and ERI1
Enzyme RegulationInhibited by Ras, probably via the interaction between RAS2 and ERI1. {ECO:0000269|PubMed:15163411}.
FunctionCatalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis
FunctionCatalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. {ECO:0000269|PubMed:10970797, ECO:0000269|PubMed:7768896}.
MiscellaneousPresent with 1480 molecules/cell in log phase SD medium
MiscellaneousPresent with 1480 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Sequence CautionSequence=CAA97882.1; Type=Erroneous gene model prediction; Evidence= ;
Sequence CautionSequence=CAA97882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein .
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
SubunitComponent of the phosphatidylinositol N- acetylglucosaminyltransferase complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1.