LMPD Database

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LMP006947

UniProt Annotations

Entry Information
Gene Nameacetyl-CoA C-acetyltransferase
Protein EntryTHIL_YEAST
UniProt IDP41338
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.16 mM for CoA {ECO:0000269|PubMed:5571829}; KM=0.35 mM for acetoacetyl-CoA {ECO:0000269|PubMed:5571829}; pH dependence: Optimum pH is 8.8. {ECO:0000269|PubMed:5571829};
Biophysicochemical PropertiesKinetic parameters: KM=0.16 mM for CoA ; KM=0.35 mM for acetoacetyl-CoA ; pH dependence: Optimum pH is 8.8. ;
Catalytic Activity2 acetyl-CoA = CoA + acetoacetyl-CoA
Catalytic Activity2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10020}.
FunctionCatalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids.
InductionInduced by low intracellular sterol levels
InductionInduced by low intracellular sterol levels. {ECO:0000269|PubMed:8754796}.
MiscellaneousPresent with 60895 molecules/cell in log phase SD medium
MiscellaneousPresent with 60895 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.
SimilarityBelongs to the thiolase family
SimilarityBelongs to the thiolase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMultimeric.