LMPD Database

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LMP006955

UniProt Annotations

Entry Information
Gene Namebifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase
Protein EntryFDFT_YEAST
UniProt IDP29704
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:8323279};
FunctionCatalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol. May also have a regulatory role regulating the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast. {ECO:0000269|PubMed:1807826, ECO:0000269|PubMed:2068081, ECO:0000269|PubMed:8323279}.
MiscellaneousPresent with 10800 molecules/cell in log phase SD medium
MiscellaneousPresent with 10800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
SimilarityBelongs to the phytoene/squalene synthase family
SimilarityBelongs to the phytoene/squalene synthase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Microsome.