LMPD Database

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LMP006977

UniProt Annotations

Entry Information
Gene Namebifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase
Protein EntryTRPG_YEAST
UniProt IDP00937
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5- phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
Catalytic ActivityChorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
InductionBy tryptophan starvation.
InteractionP00899:TRP2; NbExp=4; IntAct=EBI-19585, EBI-19575;
MiscellaneousComponent I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
MiscellaneousPresent with 13400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
MiscellaneousYeast component II C-terminal half also has indole- 3-glycerol phosphate synthase activity.
PathwayAmino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 1/5.
PathwayAmino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 4/5.
SimilarityContains 1 glutamine amidotransferase type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00605}.
SubunitTetramer of two components I and two components II.