LMPD Database

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LMP006992

UniProt Annotations

Entry Information
Gene Nameglycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Protein EntryGPD2_YEAST
UniProt IDP41911
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activitysn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
CautionIt is uncertain whether Met-1 or Met-49 is the initiator. {ECO:0000305}.
FunctionCatalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism. {ECO:0000269|PubMed:8979347}.
InductionBy anaerobic growth conditions and other conditions leading to accumulation of cytosolic NADH. {ECO:0000269|PubMed:15210723, ECO:0000269|PubMed:9171333}.
MiscellaneousPresent with 8966 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Sequence CautionSequence=CAA84532.1; Type=Frameshift; Positions=411; Evidence={ECO:0000305};
SimilarityBelongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm. Mitochondrion.