LMPD Database

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LMP007015

UniProt Annotations

Entry Information
Gene Namesqualene monooxygenase
Protein EntryERG1_YEAST
UniProt IDP32476
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivitySqualene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
Enzyme RegulationInhibited by the allylamine antimycotic drugs.
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
InteractionP35206:CSG2; NbExp=1; IntAct=EBI-6545, EBI-2051140; P53045:ERG25; NbExp=1; IntAct=EBI-6545, EBI-6506; P25340:ERG4; NbExp=1; IntAct=EBI-6545, EBI-6558; Q05359:ERP1; NbExp=1; IntAct=EBI-6545, EBI-6581; Q12450:ERP4; NbExp=1; IntAct=EBI-6545, EBI-6598; P54837:ERV25; NbExp=1; IntAct=EBI-6545, EBI-6642; P53337:ERV29; NbExp=1; IntAct=EBI-6545, EBI-23662; Q03554:GOT1; NbExp=1; IntAct=EBI-6545, EBI-2057821; P06197:PIS1; NbExp=1; IntAct=EBI-6545, EBI-13458; P14359:SNA3; NbExp=1; IntAct=EBI-6545, EBI-26122; Q02795:SWP1; NbExp=1; IntAct=EBI-6545, EBI-12666; P38845:YHR146W; NbExp=1; IntAct=EBI-6545, EBI-24770; Q02256:YVH1; NbExp=1; IntAct=EBI-6545, EBI-14322;
MiscellaneousPresent with 65400 molecules/cell in log phase SD medium
MiscellaneousPresent with 65400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
SimilarityBelongs to the squalene monooxygenase family
SimilarityBelongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitInteracts with ERG28
SubunitInteracts with ERG28. {ECO:0000269|PubMed:15995173}.