LMPD Database

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LMP007042

UniProt Annotations

Entry Information
Gene Namemedium-chain fatty acid-CoA ligase FAA2
Protein EntryLCF2_YEAST
UniProt IDP39518
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesTemperature dependence: Optimum temperature is 25 degrees Celsius.;
Biophysicochemical PropertiesTemperature dependence: Optimum temperature is 25 degrees Celsius.;
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionEsterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated.
MiscellaneousPresent with 358 molecules/cell in log phase SD medium
MiscellaneousPresent with 358 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
MiscellaneousThe FAM1-1 suppressor mutant has a single base mutation that creates a new initiator methionine and adds 18 residues at the N-terminus of the protein. This extra sequence acts as a transit peptide and the resulting protein is imported in the mitochondria.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationCytoplasm. Mitochondrion. Note=The FAM1-1 mutant is imported in the mitochondria.