LMPD Database

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LMP007099

UniProt Annotations

Entry Information
Gene Nameputative aminophospholipid-translocating P4-type ATPase NEO1
Protein EntryATC7_YEAST
UniProt IDP40527
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes. {ECO:0000269|PubMed:15314152, ECO:0000305}.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular LocationEndosome membrane {ECO:0000269|PubMed:15314152}; Multi-pass membrane protein {ECO:0000269|PubMed:15314152}. Golgi apparatus membrane {ECO:0000269|PubMed:15314152}; Multi-pass membrane protein {ECO:0000269|PubMed:15314152}.
Subcellular LocationEndosome membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
SubunitInteracts with MON2
SubunitInteracts with MON2. {ECO:0000269|PubMed:15314152}.