LMPD Database

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LMP007109

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
Protein EntryINP53_YEAST
UniProt IDQ12271
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
DomainThe 5-phosphatase domain (residues 568 to 856) selectively removes the phosphate group at the 5' position of inositol of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
DomainThe C-terminal proline-rich domain is required for the function and associates with clathrin heavy chain CHC1.
DomainThe SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
FunctionDephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN. {ECO:0000269|PubMed:10029994, ECO:0000269|PubMed:10224048, ECO:0000269|PubMed:10625610, ECO:0000269|PubMed:10628971, ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:11598201, ECO:0000269|PubMed:12686590, ECO:0000269|PubMed:15169871, ECO:0000269|PubMed:15691741, ECO:0000269|PubMed:9265642, ECO:0000269|PubMed:9560389, ECO:0000269|PubMed:9788876}.
MiscellaneousPresent with 1520 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the synaptojanin family. {ECO:0000305}.
SimilarityContains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
SimilarityIn the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:14562095}. Note=Cytoplasmic punctate structures. Hyperosmotic stress causes translocation to actin patches.
SubunitInteracts with BSP1 and CHC1. {ECO:0000269|PubMed:12606027, ECO:0000269|PubMed:12686590}.