LMPD Database

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LMP007124

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-3-phosphatase SAC1
Protein EntrySAC1_YEAST
UniProt IDP32368
SpeciesYeast (S288c)
Comments
Comment typeDescription
CautionIt is uncertain whether Met-1 or Met-59 is the initiator
CautionIt is uncertain whether Met-1 or Met-59 is the initiator. {ECO:0000305}.
FunctionPhosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton. {ECO:0000269|PubMed:10625610, ECO:0000269|PubMed:11514624}.
InteractionP38713:OSH3; NbExp=2; IntAct=EBI-16210, EBI-12630;
MiscellaneousPresent with 48000 molecules/cell in log phase SD medium
MiscellaneousPresent with 48000 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityContains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:11514624}; Single-pass membrane protein {ECO:0000269|PubMed:11514624}.
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass membrane protein .
SubunitComponent of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3
SubunitComponent of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. {ECO:0000269|PubMed:20182505}.