LMPD Database

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LMP007137

UniProt Annotations

Entry Information
Gene Nameacylglycerone-phosphate reductase
Protein EntryAYR1_YEAST
UniProt IDP40471
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=20 uM for NADPH {ECO:0000269|PubMed:1512203}; KM=15 uM for hexadecyl dihydroxyacetone-phosphate {ECO:0000269|PubMed:1512203}; Vmax=3.8 nmol/min/mg enzyme for hexadecyl dihydroxyacetone- phosphate {ECO:0000269|PubMed:1512203}; pH dependence: Optimum pH is 6.7-7.2. {ECO:0000269|PubMed:1512203}; Temperature dependence: Optimum temperature is 40 degrees Celsius. Thermostable for 10 min up to 45 degrees Celsius. {ECO:0000269|PubMed:1512203};
Catalytic Activity1-palmitoylglycerol 3-phosphate + NADP(+) = palmitoylglycerone phosphate + NADPH.
Enzyme RegulationInhibited by divalent cations and N- ethylmaleimide. Activity is reduced under anaerobic growth conditions. {ECO:0000269|PubMed:1512203}.
FunctionCan convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination. {ECO:0000269|PubMed:10617610}.
MiscellaneousPresent with 3671 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationLipid droplet. Endoplasmic reticulum.